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195 GSK-3 inhibits Wnt signalling by promoting -catenin phosphorylation and then inducing the degradation of -catenin mediated by E3 ligase

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Therefore, dysregulation of amino acid metabolism can cause metabolic reprogramming of DCs, leading to or accelerating the occurrence of various immunological disorders, like type 1 diabetes, rheumatoid arthritis, and cancer

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Cognitive dysfunction: High homocysteine levels may damage neurons and alter neurotransmitter activity